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Prostaglandin-endoperoxide synthase 2

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human enzyme involved in inflammation

Eksteraj rimedoj

identigilo de Freebase
numero en Microsoft Academic
identigilo de proteino laŭ RefSeq
identigilo de Encyclopædia Britannica Online
science/cyclooxygenase-2

nomita kiel: cyclooxygenase-2

PDB structure ID
NKCR-identigilo (Ĉeĥio)
ph430281

nomita kiel: cyklooxygenáza 2

identigilo de proteino laŭ Ensembl
UniProt protein ID

parto de

Prostaglandin G/H synthase 2[7]
Haem peroxidase domain superfamily, animal type[7]
Haem peroxidase superfamily[7]
EGF-like domain, protein family[8]

en taksono

Homo sapiens[6]

kodata de

PTGS2[6]

molekula funkcio

arachidonate 15-lipoxygenase activity[9]

determina metodo: spurebla aŭtora aserto

metal ion binding[10]

determina metodo: IEA

heme binding[11][12][13]

determina metodo: ISS, IEA

enzyme binding[14]

determina metodo: IPI

aktiveco de oksidoreduktazo[10]

determina metodo: IEA

protein homodimerization activity[13]

determina metodo: IEA

aktiveco de dioksigenazo[10]

determina metodo: IEA

proteina ligado[15]

determina metodo: IPI

aktiveco de peroksidazo[9][16][17][18]

determina metodo: IEA, NAS, spurebla aŭtora aserto

prostaglandin-endoperoxide synthase activity[9][17][18][19][20][21]

determina metodo: IEA, IDA, spurebla aŭtora aserto

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen[9][19]

determina metodo: IEA, spurebla aŭtora aserto

aktiveco de peroksidazo[22][10][12]

determina metodo: IEA, NAS

prostaglandin-endoperoxide synthase activity[10][12][13][23][24]

determina metodo: IDA, IEA

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen[13]

determina metodo: IEA

aktiveco de transdonazo[10]

determina metodo: IEA

ĉelparto

citoplasmo[11][13][25]

determina metodo: IDA, ISS, IEA

endoplasmic reticulum lumen[26]

determina metodo: spurebla aŭtora aserto

membrano[10]

determina metodo: IEA

caveola[13]

determina metodo: IEA

neuron projection[13][27]

determina metodo: IDA, IEA

organetomembrano[10]

determina metodo: IEA

endoplasma retikulo[10][28][29]

determina metodo: IDA, IEA

enĉela membrano-enfermita organeto[10]

determina metodo: IEA

membrano de endoplasma reto[30][10]

determina metodo: spurebla aŭtora aserto, IEA

makromolekula komplekso[13]

determina metodo: IEA

biologia procezo

response to fructose[13]

determina metodo: IEA

lerno[13]

determina metodo: IEA

respondo al organika substanco[13]

determina metodo: IEA

lipoxygenase pathway[30]

determina metodo: spurebla aŭtora aserto

cellular response to mechanical stimulus[13]

determina metodo: IEA

response to manganese ion[13]

determina metodo: IEA

angiogenesis[13]

determina metodo: IEA

cellular response to hypoxia[31]

determina metodo: IEP

embryo implantation[13]

determina metodo: IEA

negative regulation of cell population proliferation[13]

determina metodo: IEA

response to cytokine[13]

determina metodo: IEA

negative regulation of smooth muscle contraction[13]

determina metodo: IEA

memoro[13]

determina metodo: IEA

response to oxidative stress[12]

determina metodo: IEA

maintenance of blood-brain barrier[13]

determina metodo: IEA

respondo al litia jono[13]

determina metodo: IEA

response to tumor necrosis factor[13]

determina metodo: IEA

biosintezo de grasacido[10]

determina metodo: IEA

positive regulation of synaptic transmission, glutamatergic[13]

determina metodo: IEA

positive regulation of vasoconstriction[13]

determina metodo: IEA

response to organonitrogen compound[13]

determina metodo: IEA

inflama respondo[12][13]

determina metodo: IEA

positive regulation of smooth muscle contraction[13]

determina metodo: IEA

bone mineralization[13]

determina metodo: IEA

response to fatty acid[13]

determina metodo: IEA

response to vitamin D[13]

determina metodo: IEA

cellular response to UV[13]

determina metodo: IEA

positive regulation of fever generation[32][13]

determina metodo: ISS, IEA

cellular response to fluid shear stress[13]

determina metodo: IEA

positive regulation of synaptic plasticity[13]

determina metodo: IEA

reguligo de sanga premo[11][12][13]

determina metodo: ISS, IEA

response to lipopolysaccharide[13]

determina metodo: IEA

positive regulation of platelet-derived growth factor production[32][13]

determina metodo: ISS, IEA

regulation of inflammatory response[22]

determina metodo: NAS

brown fat cell differentiation[13]

determina metodo: IEA

sensory perception of pain[13]

determina metodo: IEA

response to radiation[13]

determina metodo: IEA

prostaglandin biosynthetic process[33][11][10][12][13]

determina metodo: NAS, ISS, IEA

cellular response to ATP[13]

determina metodo: IEA

Ovolado[13]

determina metodo: IEA

positive regulation of smooth muscle cell proliferation[13]

determina metodo: IEA

hara ciklo[13]

determina metodo: IEA

response to estradiol[13]

determina metodo: IEA

positive regulation of cell death[13]

determina metodo: IEA

positive regulation of cell migration involved in sprouting angiogenesis[34][13]

determina metodo: ISS, IEA

respondo al organika cikla kombinaĵo[13]

determina metodo: IEA

metabolo de lipido[10]

determina metodo: IEA

positive regulation of nitric oxide biosynthetic process[34][13]

determina metodo: ISS, IEA

response to glucocorticoid[13]

determina metodo: IEA

cyclooxygenase pathway[30][12][13][24]

determina metodo: IDA, spurebla aŭtora aserto, IEA

metabolo de grasa acido[10]

determina metodo: IEA

positive regulation of fibroblast growth factor production[34][13]

determina metodo: ISS, IEA

decidualization[13]

determina metodo: IEA

regulation of cell population proliferation[13]

determina metodo: IEA

positive regulation of cell population proliferation[13]

determina metodo: IEA

negative regulation of calcium ion transport[13]

determina metodo: IEA

positive regulation of apoptotic process[13]

determina metodo: IEA

positive regulation of transforming growth factor beta production[34][13]

determina metodo: ISS, IEA

positive regulation of vascular endothelial growth factor production[34][13]

determina metodo: ISS, IEA

positive regulation of brown fat cell differentiation[35][13]

determina metodo: ISS, IEA

negative regulation of synaptic transmission, dopaminergic[13]

determina metodo: IEA

cellular oxidant detoxification[36]

determina metodo: IEA

maljuniĝo[13]

determina metodo: IEA

NAD biosynthesis via nicotinamide riboside salvage pathway[30]

determina metodo: spurebla aŭtora aserto

cellular response to heat[13]

determina metodo: IEA

positive regulation of prostaglandin biosynthetic process[33][13]

determina metodo: IEA, NAS

positive regulation of peptidyl-serine phosphorylation[13]

determina metodo: IEA

negativa regado de ĉelsinmortigo[13]

determina metodo: IEA

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process[13]

determina metodo: IEA

cellular response to non-ionic osmotic stress[13]

determina metodo: IEA

negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress[13]

determina metodo: IEA

cellular response to lead ion[13]

determina metodo: IEA

response to angiotensin[13]

determina metodo: IEA

prostaglandin metabolic process[10]

determina metodo: IEA

positive regulation of protein import into nucleus[13]

determina metodo: IEA

cytokine-mediated signaling pathway[30]

determina metodo: spurebla aŭtora aserto

long-chain fatty acid biosynthetic process[30]

determina metodo: spurebla aŭtora aserto

negative regulation of cell cycle[13]

determina metodo: IEA

regulation of neuroinflammatory response[11][13]

determina metodo: IEA, ISS

fizike interagas kun

aspirino[37]

uzado: enziminhibanto

benzquinamide[38]

uzado: enziminhibanto

carprofen[39]

uzado: enziminhibanto

celecoxib[40]

uzado: enziminhibanto

diklofenako[41]

uzado: enziminhibanto

(RS)-etodolac[42]

uzado: enziminhibanto

etoricoxib[43]

uzado: enziminhibanto

(+-)-flurbiprofen[44]

uzado: enziminhibanto

ibuprofeno[45]

uzado: enziminhibanto

(RS)-ketoprofen[46]

uzado: enziminhibanto

ketorolac[47]

uzado: enziminhibanto

lumiracoxib[48]

uzado: enziminhibanto

meclofenamic acid[49]

uzado: enziminhibanto

mefenamic acid[50]

uzado: enziminhibanto

meloksikamo[51]

uzado: enziminhibanto

naproxen[52]

uzado: enziminhibanto

nimesulide[53]

uzado: enziminhibanto

NS-398[54]

uzado: enziminhibanto

oxaprozin[55]

uzado: enziminhibanto

paracetamolo[56]

uzado: enziminhibanto

phenylbutazone[57]

uzado: enziminhibanto

piroxicam[58]

uzado: enziminhibanto

resveratrolo[59]

uzado: enziminhibanto

rofecoksibo[60]

uzado: enziminhibanto

suprofen[61]

uzado: enziminhibanto

valdecoxib[62]

uzado: enziminhibanto

naproxen[63]

rolas kiel: inhibanto

diclofenac sodium[64]

rolas kiel: inhibanto

iguratimod[65]

rolas kiel: inhibanto

oxaprozin[66]

rolas kiel: inhibanto

aprikoksibo[67]

rolas kiel: inhibanto

aspirino[68]

rolas kiel: inhibanto

ibuprofeno[69]

rolas kiel: inhibanto

polmacoxib[70]

rolas kiel: inhibanto

ketorolac[71]

rolas kiel: inhibanto

isoxicam[72]

rolas kiel: inhibanto

diklofenako[73]

rolas kiel: inhibanto

(RS)-etodolac[74]

rolas kiel: inhibanto

bromfenac[75]

rolas kiel: inhibanto

(RS)-fenoprofen[76]

rolas kiel: inhibanto

diflunisal[77]

rolas kiel: inhibanto

esflurbiprofen[78]

rolas kiel: inhibanto

diclofenac potassium[79]

rolas kiel: inhibanto

(RS)-fenoprofen calcium dihydrate[80]

rolas kiel: inhibanto

ketorolac tromethamine[81]

rolas kiel: inhibanto

naproxen sodium[82]

rolas kiel: inhibanto

tolmetin sodium[83]

rolas kiel: inhibanto

numero de enzimo laŭ Enzimo-Komisiono

1.14.99.1

havas parton

EGF-like domain[7]

Komuneja kategorio

Cyclooxygenase 2

Referenco

  1. Freebase Data Dumps, 28 okt. 2013
  2. NCBI Gene, 30 maj. 2020, 5743
  3. 3,0 3,1 3,2 3,3 3,4 3,5 P35354, 9 aŭg. 2016, UniProt, angla lingvo
  4. Ensembl Release 99, ENSP00000356438
  5. Ensembl Release 99, ENSP00000454130
  6. 6,0 6,1 6,2 6,3 UniProt, 13 nov. 2019, P35354
  7. 7,0 7,1 7,2 7,3 InterPro Release 71.0, http://www.ebi.ac.uk/interpro/protein/P35354
  8. inferred from protein domain or family
  9. 9,0 9,1 9,2 9,3 spurebla aŭtora aserto, http://www.ebi.ac.uk/QuickGO/annotations?protein=P35354&geneProductId=UniProtKB:P35354, 7 nov. 2018, Reactome, GOA
  10. 10,00 10,01 10,02 10,03 10,04 10,05 10,06 10,07 10,08 10,09 10,10 10,11 10,12 10,13 10,14 10,15 IEA, 9 maj. 2019, P35354, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, UniProt
  11. 11,0 11,1 11,2 11,3 11,4 ISS, 9 maj. 2019, P35354, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, UniProt
  12. 12,0 12,1 12,2 12,3 12,4 12,5 12,6 12,7 IEA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, 9 maj. 2019, InterPro, GOA
  13. 13,00 13,01 13,02 13,03 13,04 13,05 13,06 13,07 13,08 13,09 13,10 13,11 13,12 13,13 13,14 13,15 13,16 13,17 13,18 13,19 13,20 13,21 13,22 13,23 13,24 13,25 13,26 13,27 13,28 13,29 13,30 13,31 13,32 13,33 13,34 13,35 13,36 13,37 13,38 13,39 13,40 13,41 13,42 13,43 13,44 13,45 13,46 13,47 13,48 13,49 13,50 13,51 13,52 13,53 13,54 13,55 13,56 13,57 13,58 13,59 13,60 13,61 13,62 13,63 13,64 13,65 13,66 13,67 13,68 13,69 13,70 13,71 13,72 13,73 13,74 IEA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, 9 maj. 2019, Ensembl genome database project, GOA
  14. IPI, 9 maj. 2019, P35354, Inducible nitric oxide synthase binds, S-nitrosylates, and activates cyclooxygenase-2, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, UniProt
  15. IPI, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, 9 maj. 2019, Parkinsons Disease Gene Ontology Initiative, Caveolin-1 interacts with Derlin-1 and promotes ubiquitination and degradation of cyclooxygenase-2 via collaboration with p97 complex, GOA
  16. NAS, 7 nov. 2018, P35354, Expression and localization of cyclooxygenase‐1 and ‐2 in human sporadic amyotrophic lateral sclerosis, GOA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P35354&geneProductId=UniProtKB:P35354, UniProt
  17. 17,0 17,1 IEA, 7 nov. 2018, P35354, GOA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P35354&geneProductId=UniProtKB:P35354, UniProt
  18. 18,0 18,1 IEA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P35354&geneProductId=UniProtKB:P35354, 7 nov. 2018, InterPro, GOA
  19. 19,0 19,1 IEA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P35354&geneProductId=UniProtKB:P35354, 7 nov. 2018, Ensembl genome database project, GOA
  20. IDA, 7 nov. 2018, P35354, Inducible nitric oxide synthase binds, S-nitrosylates, and activates cyclooxygenase-2, GOA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P35354&geneProductId=UniProtKB:P35354, UniProt
  21. IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P35354&geneProductId=UniProtKB:P35354, 7 nov. 2018, British Heart Foundation, Human cyclooxygenase-2 cDNA, GOA
  22. 22,0 22,1 NAS, 9 maj. 2019, P35354, Expression and localization of cyclooxygenase‐1 and ‐2 in human sporadic amyotrophic lateral sclerosis, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, UniProt
  23. IDA, 9 maj. 2019, P35354, Inducible nitric oxide synthase binds, S-nitrosylates, and activates cyclooxygenase-2, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, UniProt
  24. 24,0 24,1 IDA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, 9 maj. 2019, British Heart Foundation, Human cyclooxygenase-2 cDNA, GOA
  25. IDA, 9 maj. 2019, P35354, Expression and localization of cyclooxygenase‐1 and ‐2 in human sporadic amyotrophic lateral sclerosis, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, UniProt
  26. spurebla aŭtora aserto, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, 9 maj. 2019, Parkinsons Disease Gene Ontology Initiative, Caveolin-1 interacts with Derlin-1 and promotes ubiquitination and degradation of cyclooxygenase-2 via collaboration with p97 complex, GOA
  27. IDA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, 9 maj. 2019, Mouse Genome Informatics, Cellular localization of cyclooxygenase-1 and cyclooxygenase-2 in the normal mouse, rat, and human retina, GOA
  28. IDA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, 9 maj. 2019, Parkinsons Disease Gene Ontology Initiative, Caveolin-1 interacts with Derlin-1 and promotes ubiquitination and degradation of cyclooxygenase-2 via collaboration with p97 complex, GOA
  29. IDA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, 9 maj. 2019, Human Protein Atlas, GOA
  30. 30,0 30,1 30,2 30,3 30,4 30,5 spurebla aŭtora aserto, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, 9 maj. 2019, Reactome, GOA
  31. IEP, 9 maj. 2019, P35354, Hypoxia upregulates PGI-synthase and increases PGI₂ release in human vascular cells exposed to inflammatory stimuli, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, UniProt
  32. 32,0 32,1 ISS, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, 9 maj. 2019, British Heart Foundation, GOA
  33. 33,0 33,1 NAS, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, 9 maj. 2019, British Heart Foundation, Cyclooxygenase-2 controls energy homeostasis in mice by de novo recruitment of brown adipocytes, GOA
  34. 34,0 34,1 34,2 34,3 34,4 ISS, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, 9 maj. 2019, British Heart Foundation, Cyclooxygenase regulates angiogenesis induced by colon cancer cells, GOA
  35. ISS, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, 9 maj. 2019, British Heart Foundation, Cyclooxygenase-2 controls energy homeostasis in mice by de novo recruitment of brown adipocytes, GOA
  36. IEA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, 9 maj. 2019, Geno-Ontologia Konsorcio, GOA
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