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growth hormone releasing hormone

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kemia kombinaĵo

Eksteraj rimedoj

identigilo de Freebase
/m/08nz1m[1]
numero en Microsoft Academic
2908806039
2781042741
PubChem CID
16132353
identigilo de proteino laŭ RefSeq
NP_001171660[2]
NP_066567[2]
XP_011527086[2]
XP_011527090[2]
kodo laŭ MeSH
D06.472.699.327.740.860
D12.644.400.400.740.860
D12.644.548.365.740.860
D12.776.631.650.405.740.860
RefSeq RNA ID
NM_021081
UniProt protein ID
P01286[3]
InChIKey
JAHCMOSSKRAPEL-UHFFFAOYSA-N[4]
identigilo laŭ MeSH
D013007

nomita kiel: Growth Hormone-Releasing Hormone

PDB structure ID
5BQM[5]
numero en ChemSpider
17289012[6]
OpenAlex ID
C2781042741[7]
identigilo de Encyclopædia Britannica Online
science/growth-hormone-releasing-hormone

nomita kiel: growth hormone-releasing hormone

aŭtora noma tekstoĉeno: Robert D. Utiger

UMLS CUI
C0037668[8]
identigilo de proteino laŭ Ensembl
ENSP00000237527[9]
ENSP00000362716[10]
ENSP00000362713[11]

estas

speco de kemiaĵo

subaro de

proteino[3]

parto de

Glucagon/GIP/secretin/VIP, protein family[12]

maso

5 038,665835 daltono[4]

kemia formulo

C₂₁₅H₃₅₈N₇₂O₆₆S[4]

en taksono

Homo sapiens[3]

kodata de

GHRH[3]

molekula funkcio

growth hormone-releasing hormone receptor binding[13][14][15]

determina metodo: IEA, IPI

growth hormone-releasing hormone activity[16][17]

determina metodo: IDA

aktiveco de hormono[18]

determina metodo: IEA

neuropeptide hormone activity[19]

determina metodo: IBA

growth hormone-releasing hormone activity[20][21][19]

determina metodo: IBA, IDA

growth hormone-releasing hormone receptor binding[22][23][24][19]

determina metodo: IBA, IEA, IPI

peptide hormone receptor binding[19]

determina metodo: IBA

ĉelparto

eksterĉela regiono[25][26][27][18]

determina metodo: NAS, spurebla aŭtora aserto, IEA

terminal bouton[28][15]

determina metodo: ISS, IEA

enĉelaĵo[29]

determina metodo: IEA

eksterĉela spaco[28][15]

determina metodo: IEA, ISS

eksterĉela spaco[30][24][19]

determina metodo: IBA, IEA, ISS

neuron projection[19]

determina metodo: IBA

terminal bouton[30][24][19]

determina metodo: IBA, IEA, ISS

perikaryon[19]

determina metodo: IBA

axon terminus[31]

determina metodo: IBA

biologia procezo

response to food[30][24]

determina metodo: ISS, IEA

cell-cell signaling[32]

determina metodo: spurebla aŭtora aserto

positive regulation of insulin-like growth factor receptor signaling pathway[26]

determina metodo: NAS

growth hormone secretion[15][33]

determina metodo: IDA, IEA

adenohypophysis development[30][24]

determina metodo: ISS, IEA

positive regulation of circadian sleep/wake cycle, REM sleep[34][35]

determina metodo: NAS, IMP

positive regulation of growth hormone secretion[36][37][38][16][17]

determina metodo: NAS, IDA, IMP

positive regulation of hormone secretion[24]

determina metodo: IEA

positive regulation of cell population proliferation[15][39]

determina metodo: IDA, IEA

positive regulation of multicellular organism growth[40][41][15]

determina metodo: IEA, IMP

regulation of signaling receptor activity[42]

determina metodo: IEA

G protein-coupled receptor signaling pathway[25]

determina metodo: spurebla aŭtora aserto

adenylate cyclase-activating G protein-coupled receptor signaling pathway[28][15][38][43][44]

determina metodo: IDA, IEA, ISS

respondo al hipooksio[31]

determina metodo: IBA

adenylate cyclase-activating G protein-coupled receptor signaling pathway[30][24][45][46][47][19]

determina metodo: IBA, IDA, IEA, ISS

positive regulation of cytosolic calcium ion concentration[31]

determina metodo: IBA

positive regulation of cell population proliferation[24][48][19]

determina metodo: IBA, IDA, IEA

negative regulation of cardiac muscle cell apoptotic process[31]

determina metodo: IBA

adenohypophysis development[49][50][31]

determina metodo: IBA, IEA, ISS

growth hormone secretion[24][51][19]

determina metodo: IBA, IDA, IEA

positive regulation of insulin secretion[31]

determina metodo: IBA

positive regulation of multicellular organism growth[52][53][24][19]

determina metodo: IBA, IEA, IMP

circadian sleep/wake cycle, non-REM sleep[31]

determina metodo: IBA

response to leptin[31]

determina metodo: IBA

positive regulation of transcription, DNA-templated[31]

determina metodo: IBA

positive regulation of circadian sleep/wake cycle, non-REM sleep[31]

determina metodo: IBA

positive regulation of growth hormone secretion[26][35][45][20][21][19]

determina metodo: IBA, IDA, IMP, NAS

cellular response to calcium ion[31]

determina metodo: IBA

cellular response to interleukin-6[31]

determina metodo: IBA

response to dexamethasone[31]

determina metodo: IBA

positive regulation of lactation[31]

determina metodo: IBA

plene kongruas kun

http://purl.uniprot.org/uniprot/P01286[54]

havas parton

nitrogeno
karbono
Glucagon/GIP/secretin/VIP[55]

Referenco

  1. ↑ Freebase Data Dumps, 28 okt. 2013
  2. ↑ 2,0 2,1 2,2 2,3 NCBI Gene, 30 maj. 2020, 2691
  3. ↑ 3,0 3,1 3,2 3,3 UniProt, 13 nov. 2019, P01286
  4. ↑ 4,0 4,1 4,2 PubChem, 21 sep. 2016, angla lingvo, 44134750, Growth hormone releasing factor
  5. ↑ P01286, 9 aŭg. 2016, UniProt, angla lingvo
  6. ↑ ChemSpider, 21 sep. 2016, angla lingvo, 17289012, somatorelin
  7. ↑ OpenAlex, 26 jan. 2022, https://docs.openalex.org/download-snapshot/snapshot-data-format
  8. ↑ UMLS 2023, 24 maj. 2023, inferred by common MeSH mappings on source and on Wikidata
  9. ↑ Ensembl Release 99, ENSP00000237527
  10. ↑ Ensembl Release 99, ENSP00000362716
  11. ↑ Ensembl Release 99, ENSP00000362713
  12. ↑ inferred from protein domain or family
  13. ↑ IPI, http://www.ebi.ac.uk/QuickGO/annotations?protein=P01286&geneProductId=UniProtKB:P01286, 16 jul. 2018, British Heart Foundation, Molecular cloning and expression of a pituitary-specific receptor for growth hormone-releasing hormone, GOA
  14. ↑ IPI, http://www.ebi.ac.uk/QuickGO/annotations?protein=P01286&geneProductId=UniProtKB:P01286, 16 jul. 2018, British Heart Foundation, Molecular cloning and expression of a human anterior pituitary receptor for growth hormone-releasing hormone, GOA
  15. ↑ 15,0 15,1 15,2 15,3 15,4 15,5 15,6 IEA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P01286&geneProductId=UniProtKB:P01286, 16 jul. 2018, Ensembl genome database project, GOA
  16. ↑ 16,0 16,1 IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P01286&geneProductId=UniProtKB:P01286, 16 jul. 2018, British Heart Foundation, Congenital gigantism due to growth hormone-releasing hormone excess and pituitary hyperplasia with adenomatous transformation, GOA
  17. ↑ 17,0 17,1 IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P01286&geneProductId=UniProtKB:P01286, 16 jul. 2018, British Heart Foundation, Ghrelin alone or co-administered with GHRH or CRH increases non-REM sleep and decreases REM sleep in young males, GOA
  18. ↑ 18,0 18,1 IEA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01286, 8 apr. 2019, InterPro, GOA
  19. ↑ 19,00 19,01 19,02 19,03 19,04 19,05 19,06 19,07 19,08 19,09 19,10 19,11 19,12 IBA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01286, 8 apr. 2019, GO Central, Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium, GOA
  20. ↑ 20,0 20,1 IDA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01286, 8 apr. 2019, British Heart Foundation, Congenital gigantism due to growth hormone-releasing hormone excess and pituitary hyperplasia with adenomatous transformation, GOA
  21. ↑ 21,0 21,1 IDA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01286, 8 apr. 2019, British Heart Foundation, Ghrelin alone or co-administered with GHRH or CRH increases non-REM sleep and decreases REM sleep in young males, GOA
  22. ↑ IPI, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01286, 8 apr. 2019, British Heart Foundation, Molecular cloning and expression of a pituitary-specific receptor for growth hormone-releasing hormone, GOA
  23. ↑ IPI, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01286, 8 apr. 2019, British Heart Foundation, Molecular cloning and expression of a human anterior pituitary receptor for growth hormone-releasing hormone, GOA
  24. ↑ 24,00 24,01 24,02 24,03 24,04 24,05 24,06 24,07 24,08 24,09 IEA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01286, 8 apr. 2019, Ensembl genome database project, GOA
  25. ↑ 25,0 25,1 spurebla aŭtora aserto, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01286, 8 apr. 2019, Reactome, GOA
  26. ↑ 26,0 26,1 26,2 NAS, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01286, 8 apr. 2019, British Heart Foundation, Expression of a splice variant of the receptor for GHRH in 3T3 fibroblasts activates cell proliferation responses to GHRH analogs, GOA
  27. ↑ IEA, 8 apr. 2019, P01286, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01286, UniProt
  28. ↑ 28,0 28,1 28,2 ISS, http://www.ebi.ac.uk/QuickGO/annotations?protein=P01286&geneProductId=UniProtKB:P01286, 16 jul. 2018, British Heart Foundation, GOA
  29. ↑ IEA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P01286&geneProductId=UniProtKB:P01286, 10 sep. 2018, Geno-Ontologia Konsorcio, GOA
  30. ↑ 30,0 30,1 30,2 30,3 30,4 ISS, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01286, 8 apr. 2019, British Heart Foundation, GOA
  31. ↑ 31,00 31,01 31,02 31,03 31,04 31,05 31,06 31,07 31,08 31,09 31,10 31,11 31,12 31,13 IBA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P01286&geneProductId=UniProtKB:P01286, 10 sep. 2018, GO Central, Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium, GOA
  32. ↑ spurebla aŭtora aserto, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01286, 8 apr. 2019, Proteome Inc., Cloning and sequence analysis of cDNA for the precursor of human growth hormone-releasing factor, somatocrinin, GOA
  33. ↑ IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P01286&geneProductId=UniProtKB:P01286, 16 jul. 2018, Mouse Genome Informatics, Heterogeneity of growth-hormone deficiency, GOA
  34. ↑ NAS, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01286, 8 apr. 2019, British Heart Foundation, Ghrelin alone or co-administered with GHRH or CRH increases non-REM sleep and decreases REM sleep in young males, GOA
  35. ↑ 35,0 35,1 IMP, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01286, 8 apr. 2019, British Heart Foundation, Blockade of endogenous growth hormone-releasing hormone receptors dissociates nocturnal growth hormone secretion and slow-wave sleep, GOA
  36. ↑ NAS, http://www.ebi.ac.uk/QuickGO/annotations?protein=P01286&geneProductId=UniProtKB:P01286, 16 jul. 2018, British Heart Foundation, Expression of a splice variant of the receptor for GHRH in 3T3 fibroblasts activates cell proliferation responses to GHRH analogs, GOA
  37. ↑ IMP, http://www.ebi.ac.uk/QuickGO/annotations?protein=P01286&geneProductId=UniProtKB:P01286, 16 jul. 2018, British Heart Foundation, Blockade of endogenous growth hormone-releasing hormone receptors dissociates nocturnal growth hormone secretion and slow-wave sleep, GOA
  38. ↑ 38,0 38,1 IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P01286&geneProductId=UniProtKB:P01286, 16 jul. 2018, Mouse Genome Informatics, Receptor-associated resistance to growth hormone-releasing factor in dwarf "little" mice, GOA
  39. ↑ IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P01286&geneProductId=UniProtKB:P01286, 16 jul. 2018, British Heart Foundation, Ligand-dependent and -independent effects of splice variant 1 of growth hormone-releasing hormone receptor, GOA
  40. ↑ IMP, http://www.ebi.ac.uk/QuickGO/annotations?protein=P01286&geneProductId=UniProtKB:P01286, 16 jul. 2018, Mouse Genome Informatics, Congenital gigantism due to growth hormone-releasing hormone excess and pituitary hyperplasia with adenomatous transformation, GOA
  41. ↑ IMP, http://www.ebi.ac.uk/QuickGO/annotations?protein=P01286&geneProductId=UniProtKB:P01286, 16 jul. 2018, British Heart Foundation, Congenital gigantism due to growth hormone-releasing hormone excess and pituitary hyperplasia with adenomatous transformation, GOA
  42. ↑ IEA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01286, 8 apr. 2019, Geno-Ontologia Konsorcio, GOA
  43. ↑ IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P01286&geneProductId=UniProtKB:P01286, 16 jul. 2018, British Heart Foundation, Molecular cloning and expression of a pituitary-specific receptor for growth hormone-releasing hormone, GOA
  44. ↑ IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P01286&geneProductId=UniProtKB:P01286, 16 jul. 2018, British Heart Foundation, Molecular cloning and expression of a human anterior pituitary receptor for growth hormone-releasing hormone, GOA
  45. ↑ 45,0 45,1 IDA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01286, 8 apr. 2019, Mouse Genome Informatics, Receptor-associated resistance to growth hormone-releasing factor in dwarf "little" mice, GOA
  46. ↑ IDA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01286, 8 apr. 2019, British Heart Foundation, Molecular cloning and expression of a pituitary-specific receptor for growth hormone-releasing hormone, GOA
  47. ↑ IDA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01286, 8 apr. 2019, British Heart Foundation, Molecular cloning and expression of a human anterior pituitary receptor for growth hormone-releasing hormone, GOA
  48. ↑ IDA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01286, 8 apr. 2019, British Heart Foundation, Ligand-dependent and -independent effects of splice variant 1 of growth hormone-releasing hormone receptor, GOA
  49. ↑ ISS, http://www.ebi.ac.uk/QuickGO/annotations?protein=P01286&geneProductId=UniProtKB:P01286, 10 sep. 2018, British Heart Foundation, GOA
  50. ↑ IEA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P01286&geneProductId=UniProtKB:P01286, 10 sep. 2018, Ensembl genome database project, GOA
  51. ↑ IDA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01286, 8 apr. 2019, Mouse Genome Informatics, Heterogeneity of growth-hormone deficiency, GOA
  52. ↑ IMP, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01286, 8 apr. 2019, Mouse Genome Informatics, Congenital gigantism due to growth hormone-releasing hormone excess and pituitary hyperplasia with adenomatous transformation, GOA
  53. ↑ IMP, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01286, 8 apr. 2019, British Heart Foundation, Congenital gigantism due to growth hormone-releasing hormone excess and pituitary hyperplasia with adenomatous transformation, GOA
  54. ↑ Identifiers.org
  55. ↑ InterPro Release 71.0, http://www.ebi.ac.uk/interpro/protein/P01286
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